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KMID : 0545119950050030154
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Journal of Microbiology and Biotechnology
1995 Volume.5 No. 3 p.154 ~ p.157
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des-Asp^4-Amastatin, MRK-22 as an Inhibitor of Aminopeptidase m produced by Streptomyces sp. SL20209
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Ko, Hack Ryong
Chun, Hyo Kon/Kim, Seung Ho/Sung, Nack Kie/Kho, Yung Hee
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Abstract
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MRK-22, an inhibitor of aminopeptidase M was isolated from the culture broth of Streptomyces sp. SL20209. The structure of MRK-22 was defined to be 3-amino-2-hydroxy-5-methylhexanoyl-valyl-valine, des-Asp^4-amastatin, by spectroscopic analysis and this was also confirmed by solid phase synthesis of the inhibitor. The molecular formula and weight of MRK-22 were C_17H_33O_5 and MW 359(M^+), respectively, and its IC_50 value against hog kidney AP-M was 0.79 ㎍/㎖.
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